Epigenetics and Primal Therapy

Epigenetics and Cancer Therapy

Epigenetic approach in treating different diseases has gained importance as the inhibition of the enzymes involved in epigenetic modifications can reverse the disease condition. The major epigenetic markers include DNA methylation, histone acetylation and methylation that alter chromatin structure resulting in changes in cellular functions. The DNA methylation and histone modifications in cance...

Epigenetics and Targeted Therapy in Acute Leukemia

Chromatin is a highly ordered structure consisting of repeats of nucleosomes connected by linker DNA. It consists of DNA, histone, and nonhistone proteins condensed into nucleoprotein complexes and it functions as the physiological template of all eukaryotic genetic information. Histones are small basic proteins containing a globular domain and a flexible charged NH2 terminus known as the histo...

Cancer Epigenetics: From Mechanism to Therapy

The epigenetic regulation of DNA-templated processes has been intensely studied over the last 15 years. DNA methylation, histone modification, nucleosome remodeling, and RNA-mediated targeting regulate many biological processes that are fundamental to the genesis of cancer. Here, we present the basic principles behind these epigenetic pathways and highlight the evidence suggesting that their mi...

Up Against the Wall: Primal Therapy and 'the Sixties'

Epigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy

Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by homozygous expansion of a GAA·TTC trinucleotide repeat within the first intron of the FXN gene, leading to reduced FXN transcription and decreased levels of frataxin protein. Recent advances in FRDA research have revealed the presence of several epigenetic modifications that are either directly or indirect...